The two-bucket problem of unproven stem cell interventions

Research output: Contribution to journalEditorialpeer-review


The two-bucket problem of unproven stem cell interventions (SCIs) continues to bifurcate good (ethical) from bad (unethical) practices in the translation of stem cell medicine in ways that divert attention from other salient and challenging questions. It causes scholars to focus narrowly on reprimanding bad actors through legal and regulatory approaches and distracts from other important considerations such as how best to balance evidence with unmet patient needs and address misinformation about unproven stem cell interventions potentially changing patient behavior. The stem cell science community needs to consider a range of ethical practices and aim to address important questions that have yet not received sufficient consideration.

Original languageEnglish (US)
Pages (from-to)19-21
Number of pages3
JournalRegenerative Medicine
Issue number1
StatePublished - Jan 1 2023


  • clinical evidence
  • evidentiary standards
  • regulations
  • unmet patient needs
  • unproven stem cell interventions

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology


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