The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury

Petr Krupa, Ahad M. Siddiqui, Peter J. Grahn, Riazul Islam, Bingkun K. Chen, Nicolas N. Madigan, Anthony J. Windebank, Igor A. Lavrov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Evidence from preclinical and clinical research suggest that neuromodulation technologies can facilitate the sublesional spinal networks, isolated from supraspinal commands after spinal cord injury (SCI), by reestablishing the levels of excitability and enabling descending motor signals via residual connections. Herein, we evaluate available evidence that sublesional and supralesional spinal circuits could form a translesional spinal network after SCI. We further discuss evidence of translesional network reorganization after SCI in the presence of sensory inputs during motor training. In this review, we evaluate potential mechanisms that underlie translesional circuitry reorganization during neuromodulation and rehabilitation in order to enable motor functions after SCI. We discuss the potential of neuromodulation technologies to engage various components that comprise the translesional network, their functional recovery after SCI, and the implications of the concept of translesional network in development of future neuromodulation, rehabilitation, and neuroprosthetics technologies.

Original languageEnglish (US)
Pages (from-to)163-179
Number of pages17
Issue number2
StatePublished - Apr 2022


  • CPG
  • discomplete spinal cord injury
  • neuromodulation
  • neuroplasticity
  • regeneration
  • spinal cord injury
  • translesional spinal network

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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