The SWI/SNF complex and cancer

D. Reisman; S. Glaros; E. A. Thompson

doi:10.1038/onc.2009.4

The SWI/SNF complex and cancer

D. Reisman, S. Glaros, E. A. Thompson

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

435 Scopus citations

Abstract

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

Original language	English (US)
Pages (from-to)	1653-1668
Number of pages	16
Journal	Oncogene
Volume	28
Issue number	14
DOIs	https://doi.org/10.1038/onc.2009.4
State	Published - Apr 9 2009

Keywords

BAF47
BRG1
BRM
Chromatin remodeling
Tumor suppressor

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/onc.2009.4

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The SWI/SNF complex and cancer

Abstract

Keywords

ASJC Scopus subject areas

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