The snRNP e protein multigene family contains five pseudogenes with common mutations

David R. Stanford, Eileen L. Holicky, Caroline A. Perry, Kai Rehder, Scott E. Harvey, Anne M. Rohleder, Eric D. Wieben

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Sequence data from three previously-uncharacterized members of the snRNP E protein multigene family suggest that each is a non-transcribed processed pseudogene, even though one clone has the potential to code for a full-length protein with greater than 90% similarity to previously-characterized E protein cDNAs. Each of the newly-analyzed family members is without introns, contains a tract of polyadenylic acid residues, and is flanked by short direct repeats. In addition, the three sequences all contain point mutations that distinguish them from the E protein coding sequence. Seven point mutations are common to the three sequences described here and to two previously-described E protein pseudogenes. Although all of these mutations are tran sitions, only 5 of 7 could have been generated by deamination of methylated cytosines in inactive genes. Thus, the common muta tions in the pseudogenes suggest an origin other than the expressed gene that we have described. Allelic variants for two of the pseudogenes were detected and repetitive elements are located near four of the five E protein pseudogenes that have been characterized.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalMitochondrial DNA
Issue number5
StatePublished - 1991


  • Autoimmune antigen
  • Gene structure
  • Pseudoge nes
  • Repetitive elements
  • SnRNP protein
  • Splicing component

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'The snRNP e protein multigene family contains five pseudogenes with common mutations'. Together they form a unique fingerprint.

Cite this