The small nuclear RNAs of Drosophila

Evelyne Myslinski, Christiane Branlant, Eric D. Wieben, Thoru Pederson

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


We have investigated the sequences of the major small nuclear RNAs of Drosophila cultured cells, with the objective of elucidating phylogenetically conserved primary and secondary structures by comparison of the data with previously determined sequences of these RNAs in vertebrate species. Our results reveal striking degrees of conservation between each Drosophila RNA and its vertebrate cognate, and also demonstrate blocks of homology among the Drosophila small nuclear RNAs, as previously described for vertebrates. The most conserved features include the 5′ terminal region of U1 RNA, thought to function in pre-mRNA splicing, most of the regions of U4 RNA recently implicated in 3′ processing of pre-mRNA, and the major snRNP protein binding site ("domain A") that is also shared by vertebrate U1, U2, U4 and U5 RNAs. Several other conserved features have been revealed, suggesting additional regions of functional significance in these RNAs and also providing further insights into the evolutionary history of the small nuclear RNAs.

Original languageEnglish (US)
Pages (from-to)927-945
Number of pages19
JournalJournal of Molecular Biology
Issue number4
StatePublished - Dec 25 1984

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Structural Biology


Dive into the research topics of 'The small nuclear RNAs of Drosophila'. Together they form a unique fingerprint.

Cite this