Abstract
To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.
Original language | English (US) |
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Pages (from-to) | 1297-1300 |
Number of pages | 4 |
Journal | Leukemia Research |
Volume | 35 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2011 |
Keywords
- Acute myeloid leukemia
- Cytogenetics
- Myelodysplasia
- Y chromosome loss
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research