The Second Canadian Conference on Multiple Sclerosis

Brian G. Weinshenker, Robert Nelson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The epidemiology of multiple sclerosis (MS) and the planning and interpretation of clinical therapeutic trials were the subjects of a symposium on MS held on June 13, 1989. Several speakers addressed whether MS is a genetic or an environmental disease. An environmental trigger would resolve the relatively low penetrance of the disease in susceptible individuals, although the alternative hypothesis that MS is a multigenic disease would also account for this observation. Clinical trials have to date failed to confirm the efficacy of any immunosuppressive or other agent in the management of progressive MS. Magnetic resonance imaging (MRI) appears to be highly sensitive for monitoring the activity of MS. Preliminary evidence suggests that MRI activity correlates with longitudinal clinical assessments of disability. Immunologic tests, while valuable in determining pathophysiology of MS, have not been strongly correlated with clinical outcome.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Issue number1
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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