The role of Raptor in lymphocytes differentiation and function

Jianing Tang; Lu Yang; Fei Guan; Heather Miller; Niels Olsen Saraiva Camara; Louisa K. James; Kamel Benlagha; Masato Kubo; Steffen Heegaard; Pamela Lee; Jiahui Lei; Hu Zeng; Chengwei He; Zhimin Zhai; Chaohong Liu

doi:10.3389/fimmu.2023.1146628

The role of Raptor in lymphocytes differentiation and function

Jianing Tang, Lu Yang, Fei Guan, Heather Miller, Niels Olsen Saraiva Camara, Louisa K. James, Kamel Benlagha, Masato Kubo, Steffen Heegaard, Pamela Lee, Jiahui Lei, Hu Zeng, Chengwei He, Zhimin Zhai, Chaohong Liu

Rheumatology

Research output: Contribution to journal › Review article › peer-review

Abstract

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

Original language	English (US)
Article number	1146628
Journal	Frontiers in immunology
Volume	14
DOIs	https://doi.org/10.3389/fimmu.2023.1146628
State	Published - 2023

Keywords

B cell
Raptor
T cell
immune
mTORC1

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.3389/fimmu.2023.1146628

Cite this

@article{2b18cb2257ef45b6b35417cd26cf6775,

title = "The role of Raptor in lymphocytes differentiation and function",

abstract = "Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.",

keywords = "B cell, Raptor, T cell, immune, mTORC1",

author = "Jianing Tang and Lu Yang and Fei Guan and Heather Miller and Camara, {Niels Olsen Saraiva} and James, {Louisa K.} and Kamel Benlagha and Masato Kubo and Steffen Heegaard and Pamela Lee and Jiahui Lei and Hu Zeng and Chengwei He and Zhimin Zhai and Chaohong Liu",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 Tang, Yang, Guan, Miller, Camara, James, Benlagha, Kubo, Heegaard, Lee, Lei, Zeng, He, Zhai and Liu.",

year = "2023",

doi = "10.3389/fimmu.2023.1146628",

language = "English (US)",

volume = "14",

journal = "Frontiers in immunology",

issn = "1664-3224",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - The role of Raptor in lymphocytes differentiation and function

AU - Tang, Jianing

AU - Yang, Lu

AU - Guan, Fei

AU - Miller, Heather

AU - Camara, Niels Olsen Saraiva

AU - James, Louisa K.

AU - Benlagha, Kamel

AU - Kubo, Masato

AU - Heegaard, Steffen

AU - Lee, Pamela

AU - Lei, Jiahui

AU - Zeng, Hu

AU - He, Chengwei

AU - Zhai, Zhimin

AU - Liu, Chaohong

PY - 2023

Y1 - 2023

N2 - Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

AB - Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

KW - B cell

KW - Raptor

KW - T cell

KW - immune

KW - mTORC1

UR - http://www.scopus.com/inward/record.url?scp=85161006694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85161006694&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2023.1146628

DO - 10.3389/fimmu.2023.1146628

M3 - Review article

C2 - 37283744

AN - SCOPUS:85161006694

SN - 1664-3224

VL - 14

JO - Frontiers in immunology

JF - Frontiers in immunology

M1 - 1146628

ER -

The role of Raptor in lymphocytes differentiation and function

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this