The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development

Chuan Chen, Jinghua Hu, Kun Ling

Research output: Contribution to journalReview articlepeer-review


Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to a pleiotropic group of developmental disorders, termed ciliopathy. Phosphoinositides (PIs), a group of signaling phospholipids, play a crucial role in development and tissue homeostasis by regulating membrane trafficking, cytoskeleton reorganization, and organelle identity. Accumulating evidence implicates the involvement of PI species in ciliary defects and ciliopathies. The abundance and localization of PIs in the cell are tightly regulated by the opposing actions of kinases and phosphatases, some of which are recently discovered in the context of primary cilia. Here, we review several cilium-associated PI kinases and phosphatases, including their localization along cilia, function in regulating the ciliary biology under normal conditions, as well as the connection of their disease-associated mutations with ciliopathies.

Original languageEnglish (US)
Article number51
JournalJournal of Developmental Biology
Issue number4
StatePublished - Dec 2022


  • development
  • phosphoinositide kinases and phosphatases
  • primary cilia

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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