The Role of Partial Nephrectomy for the Management of Sporadic Renal Angiomyolipoma

Stephen A. Boorjian, Igor Frank, Brant Inman, Christine M. Lohse, John C. Cheville, Bradley C. Leibovich, Michael L. Blute

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Objectives: Angiomyolipoma is a benign renal tumor that has a propensity to grow over time and may cause local complications. Given the benign nature of these lesions, renal-preserving treatments are favored. We evaluated our experience with nephron-sparing surgery for renal angiomyolipoma. Methods: We reviewed our institutional nephrectomy registry to identify patients treated with nephron-sparing surgery for renal angiomyolipoma between 1970 and 2004. Patients with a diagnosis of tuberous sclerosis were excluded. Patient demographics, perioperative complications, and postoperative outcomes were recorded. Results: We identified 58 patients treated with nephron-sparing surgery for sporadic renal angiomyolipoma, including 44 women and 14 men. The median tumor size was 3.9 cm (range, 0.8-12.5 cm). In 7 patients (12%), several ipsilateral angiomyolipomas were resected, whereas 2 patients were treated with nephron-sparing surgery for bilateral angiomyolipomas. The overall early complication rate was 12%, including a urine leak in 3 (5%) patients. At a median postoperative follow-up of 8 years (range, 1-31 years), 2 (3.4%) patients had radiographic evidence of local recurrence, although no patient experienced symptom recurrence. The median preoperative serum creatinine level was 1.0 mg/dL (range, 0.5-3.9 mg/dL), and the median creatinine level at last follow-up was 1.1 mg/dL (range, 0.6-3.6 mg/dL). No patient developed de novo chronic renal insufficiency after nephron-sparing surgery, including 4 patients treated for angiomyolipomas in a solitary kidney. Conclusions: Nephron-sparing surgery for sporadic renal angiomyolipomas offers preservation of renal function and is associated with acceptable complication and low local recurrence rates. The results of this study support nephron-sparing surgery for these lesions.

Original languageEnglish (US)
Pages (from-to)1064-1068
Number of pages5
Issue number6
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Urology


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