The role of mitochondria in calcium regulation in airway smooth muscle

Philippe Delmotte, Li Jia, Gary C. Sieck

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Excitation-contraction coupling represents a cascade of events that connects the initiating signal, an elevation of cytosolic Ca2+ concentration ([Ca2+]cyt), with the ensuing cross-bridge recruitment and cycling that underlies ATP-consuming mechanical work. Mitochondria are the power plant of the cell. An elevation in [Ca2+]cyt is followed by an increase in mitochondrial Ca2+ ([Ca2+]mito). Moreover, an increase in [Ca2+]mito leads to an increase in ATP production. Therefore, the relationship between elevations in [Ca2+]cyt and [Ca2+]mito reflects a coupling between energy demand and energy supply. Accordingly, mitochondrial Ca2+ regulation mediates excitation-energy coupling in ASM. To this end, mitochondrial movement within ASM cells may help couple ATP production to localized differences in energy demand.

Original languageEnglish (US)
Title of host publicationCalcium Signaling In Airway Smooth Muscle Cells
PublisherSpringer International Publishing
Number of pages24
ISBN (Electronic)9783319013121
ISBN (Print)3319013114, 9783319013114
StatePublished - Nov 1 2014


  • ATP
  • Cytosolic Ca
  • Excitation-Contraction Coupling
  • Metabolism
  • Mitochondrial Ca

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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