TY - JOUR
T1 - The role of integrins in melanoma
T2 - a review
AU - Arias-Mejias, Suzette M.
AU - Warda, Katerina Y.
AU - Quattrocchi, Enrica
AU - Alonso-Quinones, Hector
AU - Sominidi-Damodaran, Sindhuja
AU - Meves, Alexander
N1 - Publisher Copyright:
© 2020 the International Society of Dermatology
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Integrins are the major family of cell adhesion receptors in humans and essential for a wide range of normal physiology, including formation and maintenance of tissue structure integrity, cell migration, proliferation, and differentiation. Integrins also play a prominent role in tumor growth and metastasis. Translational research has tried to define the contribution of integrins to the phenotypic aggressiveness of melanoma because such knowledge is clinically useful. For example, differential expression of integrins in primary cutaneous melanoma can be used to distinguish indolent from aggressive, prometastatic melanoma. Recent studies have shown that gene expression–based testing of patient-derived melanoma tissue is feasible, and molecular tests may fully replace interventional surgical methods such as sentinel lymph node biopsies in the future. Because of their central role in mediating invasion and metastasis, integrins are likely to be useful biomarkers. Integrins are also attractive candidate targets for interventional therapy. This article focuses on the role of integrins in melanoma and highlights recent advances in the field of translational research.
AB - Integrins are the major family of cell adhesion receptors in humans and essential for a wide range of normal physiology, including formation and maintenance of tissue structure integrity, cell migration, proliferation, and differentiation. Integrins also play a prominent role in tumor growth and metastasis. Translational research has tried to define the contribution of integrins to the phenotypic aggressiveness of melanoma because such knowledge is clinically useful. For example, differential expression of integrins in primary cutaneous melanoma can be used to distinguish indolent from aggressive, prometastatic melanoma. Recent studies have shown that gene expression–based testing of patient-derived melanoma tissue is feasible, and molecular tests may fully replace interventional surgical methods such as sentinel lymph node biopsies in the future. Because of their central role in mediating invasion and metastasis, integrins are likely to be useful biomarkers. Integrins are also attractive candidate targets for interventional therapy. This article focuses on the role of integrins in melanoma and highlights recent advances in the field of translational research.
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U2 - 10.1111/ijd.14850
DO - 10.1111/ijd.14850
M3 - Review article
C2 - 32157692
AN - SCOPUS:85081272863
SN - 0011-9059
VL - 59
SP - 525
EP - 534
JO - International journal of dermatology
JF - International journal of dermatology
IS - 5
ER -