The role of glutathione in the transport and catabolism of nitric oxide

Neil Hogg, Ravinder J. Singh, B. Kalyanaraman

Research output: Contribution to journalArticlepeer-review

239 Scopus citations


Nitric oxide acts as a neuronal and vascular messenger implying diffusion through intracellular environments containing 5-10 mM glutathione. Nitric oxide reacts with glutathione under aerobic conditions generating S-nitrosoglutathione (GSNO). GSNO reacts with glutathione (k = 8.3 x 10-3 M-1 · s-1) to generate nitrous oxide and glutathione disulfide (GSSG), Anaerobically, glutathione reacts with nitric oxide generating nitrous oxide and GSSG (k = 4.8 x 10-4 s-1 at 5 mM GSH). In both aerobic and anaerobic situations the nitroxyl anion may be an intermediate in the synthesis of nitrous oxide and, under aerobic conditions, nitroxyl anion may generate peroxynitrite. We present a hypothesis for the intracellular interaction between nitric oxide and glutathione.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalFEBS Letters
Issue number3
StatePublished - Mar 18 1996


  • Glutathione
  • Nitric oxide
  • Nitrosothiol
  • Nitrous oxide
  • Peroxynitrite

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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