Abstract
Nitric oxide acts as a neuronal and vascular messenger implying diffusion through intracellular environments containing 5-10 mM glutathione. Nitric oxide reacts with glutathione under aerobic conditions generating S-nitrosoglutathione (GSNO). GSNO reacts with glutathione (k = 8.3 x 10-3 M-1 · s-1) to generate nitrous oxide and glutathione disulfide (GSSG), Anaerobically, glutathione reacts with nitric oxide generating nitrous oxide and GSSG (k = 4.8 x 10-4 s-1 at 5 mM GSH). In both aerobic and anaerobic situations the nitroxyl anion may be an intermediate in the synthesis of nitrous oxide and, under aerobic conditions, nitroxyl anion may generate peroxynitrite. We present a hypothesis for the intracellular interaction between nitric oxide and glutathione.
Original language | English (US) |
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Pages (from-to) | 223-228 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 382 |
Issue number | 3 |
DOIs | |
State | Published - Mar 18 1996 |
Keywords
- Glutathione
- Nitric oxide
- Nitrosothiol
- Nitrous oxide
- Peroxynitrite
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology