The Role of Genetics in IBS

Yuri A. Saito

doi:10.1016/j.gtc.2010.12.011

The Role of Genetics in IBS

Yuri A. Saito

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

Original language	English (US)
Pages (from-to)	45-67
Number of pages	23
Journal	Gastroenterology Clinics of North America
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/j.gtc.2010.12.011
State	Published - Mar 2011

Keywords

Complex genetic disease
Gene
Genetics
Irritable bowel syndrome

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2010.12.011

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abstract = "Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.",

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N2 - Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

AB - Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

KW - Complex genetic disease

KW - Gene

KW - Genetics

KW - Irritable bowel syndrome

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The Role of Genetics in IBS

Abstract

Keywords

ASJC Scopus subject areas

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