Abstract
Exosomes are cell-free membrane vesicles secreted by a wide variety of cells as secretomes into the extracellular matrix. Alongside facilitating intercellular communication, exosomes carry various bioactive molecules consisting of nucleic acids, proteins, and lipids. Exosome applications have increased in popularity by overcoming the disadvantages of mesenchymal stem cell therapies. Despite this, a better understanding of the underlying mechanisms of action of exosomes is necessary prior to clinical application in upper-extremity tissue regeneration. The purpose of this review is to introduce the concept of exosomes and their possible applications in upper-extremity tissue regeneration, detail the shortcomings of current exosome research, and explore their potential clinical application in the upper extremity.
Original language | English (US) |
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Pages (from-to) | 170-178 |
Number of pages | 9 |
Journal | Journal of Hand Surgery |
Volume | 49 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2024 |
Keywords
- Basic science
- exosomes
- regenerative medicine
- tissue regeneration
- upper extremity injuries
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine