The role of eosinophils in rhinologic diseases

Jens Ponikau, Hirohito Kita, David A. Sherris

Research output: Chapter in Book/Report/Conference proceedingChapter


The eosinophil granulocyte, although likely first observed by Wharton Jones in 1846 in unstained preparations of peripheral blood, was so named by Paul Ehrlich in 1879 because of the intense staining of its granules with the acidic dye eosin Gleich and Adolphson (Adv Immunol 39:177-253, 1986). Since that time, the eosinophil has been the subject of extensive investigation. Its occurrence in such disparate conditions as parasitic infections, presumably for the benefit of the human host, and hypersensitivity diseases, perhaps to the detriment of the patient, although paradoxical, has become better understood as a consequence of newer information. Eosinophils are resident and nonpathologic in various organs such as gastrointestinal tract and mammary glands, and they may play roles in tissue and immune homeostasis of these organs.

Original languageEnglish (US)
Title of host publicationNasal Physiology and Pathophysiology of Nasal Disorders
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages14
ISBN (Print)9783642372506, 364237249X, 9783642372490
StatePublished - Nov 1 2013


  • Chronic Rhinosinusits
  • Eosinophil
  • Innate and Acquired Immunity
  • Major Basic Protein (MBP)
  • Sinusitis

ASJC Scopus subject areas

  • General Medicine


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