The role of eosinophils in rhinologic diseases

Jens Ponikau; Hirohito Kita; David A. Sherris

doi:10.1007/978-3-642-37250-6_8

The role of eosinophils in rhinologic diseases

Jens Ponikau, Hirohito Kita, David A. Sherris

Allergy, Asthma and Clinical Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The eosinophil granulocyte, although likely first observed by Wharton Jones in 1846 in unstained preparations of peripheral blood, was so named by Paul Ehrlich in 1879 because of the intense staining of its granules with the acidic dye eosin Gleich and Adolphson (Adv Immunol 39:177-253, 1986). Since that time, the eosinophil has been the subject of extensive investigation. Its occurrence in such disparate conditions as parasitic infections, presumably for the benefit of the human host, and hypersensitivity diseases, perhaps to the detriment of the patient, although paradoxical, has become better understood as a consequence of newer information. Eosinophils are resident and nonpathologic in various organs such as gastrointestinal tract and mammary glands, and they may play roles in tissue and immune homeostasis of these organs.

Original language	English (US)
Title of host publication	Nasal Physiology and Pathophysiology of Nasal Disorders
Publisher	Springer-Verlag Berlin Heidelberg
Pages	95-108
Number of pages	14
ISBN (Electronic)	9783642372506
ISBN (Print)	364237249X, 9783642372490
DOIs	https://doi.org/10.1007/978-3-642-37250-6_8
State	Published - Nov 1 2013

Keywords

Chronic Rhinosinusits
Eosinophil
Innate and Acquired Immunity
Major Basic Protein (MBP)
Sinusitis

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-642-37250-6_8

Cite this

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abstract = "The eosinophil granulocyte, although likely first observed by Wharton Jones in 1846 in unstained preparations of peripheral blood, was so named by Paul Ehrlich in 1879 because of the intense staining of its granules with the acidic dye eosin Gleich and Adolphson (Adv Immunol 39:177-253, 1986). Since that time, the eosinophil has been the subject of extensive investigation. Its occurrence in such disparate conditions as parasitic infections, presumably for the benefit of the human host, and hypersensitivity diseases, perhaps to the detriment of the patient, although paradoxical, has become better understood as a consequence of newer information. Eosinophils are resident and nonpathologic in various organs such as gastrointestinal tract and mammary glands, and they may play roles in tissue and immune homeostasis of these organs.",

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N2 - The eosinophil granulocyte, although likely first observed by Wharton Jones in 1846 in unstained preparations of peripheral blood, was so named by Paul Ehrlich in 1879 because of the intense staining of its granules with the acidic dye eosin Gleich and Adolphson (Adv Immunol 39:177-253, 1986). Since that time, the eosinophil has been the subject of extensive investigation. Its occurrence in such disparate conditions as parasitic infections, presumably for the benefit of the human host, and hypersensitivity diseases, perhaps to the detriment of the patient, although paradoxical, has become better understood as a consequence of newer information. Eosinophils are resident and nonpathologic in various organs such as gastrointestinal tract and mammary glands, and they may play roles in tissue and immune homeostasis of these organs.

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The role of eosinophils in rhinologic diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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