The role of brain-derived neurotrophic factor in different animal models of neuropathic pain

Pascal Vanelderen, Tom Rouwette, Tamas Kozicz, Eric Roubos, Jan Van Zundert, Rene Heylen, Kris Vissers

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to treat and a challenge for researchers to investigate. Different animal models have been developed to mimic neuropathic pain. Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 have been studied extensively in these models, yet few review articles concerning brain-derived neurotrophic factor have been published. This article reassesses the literature concerning brain-derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain-derived neurotrophic factor between these models and their causality with neuropathic pain.

Original languageEnglish (US)
Pages (from-to)473.e1-473.e9
JournalEuropean Journal of Pain
Issue number5
StatePublished - May 2010


  • ATF3
  • BDNF
  • Brain-derived neurotrophic factor
  • CCI
  • DH
  • DRG
  • Dorsal root ganglion
  • ERK
  • IR
  • JNK
  • Jun N-terminal kinase
  • KCC2
  • MAPK
  • NGF
  • NPY
  • NT3
  • NT4
  • NT5
  • Neurotrophins
  • P75NTR
  • SNL
  • SNT
  • Sciatic nerve
  • Spinal nerve
  • activating transcription factor 3
  • brain-derived neurotrophic factor
  • chronic constriction injury
  • dorsal horn
  • dorsal root ganglion
  • extracellular signal-regulated protein kinases
  • i.t.
  • immunoreactive
  • intrathecally
  • mitogen activated protein kinase
  • nerve growth factor
  • neuropeptide Y
  • neurotrophin 3
  • neurotrophin 4
  • neurotrophin 5
  • p75 neurotrophin receptor
  • potassium-chloride co-transporter 2
  • spinal nerve ligation
  • spinal nerve transection

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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