The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders

Sayantani B. Sindher, Suzanne Barshow, Jyothi Tirumalasetty, Stefania Arasi, Dan Atkins, Maureen Bauer, Philippe Bégin, Margaret H. Collins, Antoine Deschildre, Alfred D. Doyle, Alessandro Fiocchi, Glenn T. Furuta, Maria Garcia-Lloret, Maurizio Mennini, Marc E. Rothenberg, Jonathan M. Spergel, Julie Wang, Robert A. Wood, Benjamin L. Wright, Torsten ZuberbierAndrew R. Chin, Andrew Long, Kari C. Nadeau, R. Sharon Chinthrajah

Research output: Contribution to journalReview articlepeer-review


Continuing insight into the molecular mechanisms of atopic disorders has enabled the development of biologics to precisely target these diseases. Food allergy (FA) and eosinophilic gastrointestinal disorders (EGIDs) are driven by similar inflammatory molecular mechanisms and exist along the same atopic disease spectrum. Therefore, many of the same biologics are being investigated to target key drivers of mechanisms shared across the disease states. The enormous potential of biologics for the treatment of FA and EGIDs is highlighted by the significant increases in the number of ongoing clinical trials (more than 30) evaluating their use in these disease states, as well as by the recent US Food and Drug Administration approval of dupilumab for the treatment of eosinophilic esophagitis. Here we discuss past and current research into the use of biologics in FA and EGIDs and their potential role in improving treatment options in the future, with the need to have biologics widely clinically available.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalJournal of Allergy and Clinical Immunology
Issue number3
StatePublished - Mar 2023


  • Food allergy
  • biologics
  • eosinophilic colitis
  • eosinophilic enteritis
  • eosinophilic esophagitis
  • eosinophilic gastritis
  • eosinophilic gastrointestinal disorders
  • oral immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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