The role of autoreactive T-cell hybridomas from autoimmune model mice

S. Yanoma, I. Aoki, N. Ishii, K. Tani, C. S. David, K. Okuda

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Auto reactive IL-2-producing T-cell hybridomas were established from New Zealand Black and White (B/W) F1 and MRL/1 mice. In B/WF1 mice the frequency of IL-2-producing hybridomas increased with age. It is necessary for the cells to recognize autologous MHC molecules in order to release IL-2. Inoculation of hybridoma cells into several mouse strains via the footpad produced significant swelling responses in an H-2-restricted manner. Finally, several autoimmune abnormalities were induced in naive H-2-compatible mice by i.v. inoculation of certain hybridoma cells. These results demonstrate that self-MHC molecule recognition by T cells plays an important role in the development of autoimmunity.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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