The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Jennifer L. Whitwell; Peter Martin; Jonathan Graff-Radford; Mary M. Machulda; Matthew L. Senjem; Christopher G. Schwarz; Stephen D. Weigand; Anthony J. Spychalla; Daniel A. Drubach; Clifford R. Jack; Val J. Lowe; Keith A. Josephs

doi:10.1016/j.jalz.2018.12.016

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Jennifer L. Whitwell, Peter Martin, Jonathan Graff-Radford, Mary M. Machulda, Matthew L. Senjem, Christopher G. Schwarz, Stephen D. Weigand, Anthony J. Spychalla, Daniel A. Drubach, Clifford R. Jack, Val J. Lowe, Keith A. Josephs

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Introduction: Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD). Methods: Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model. Results: Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance. Discussion: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.

Original language	English (US)
Pages (from-to)	675-685
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.jalz.2018.12.016
State	Published - May 2019

Keywords

AV-1451
Amyloid
Magnetic resonance imaging
Pittsburgh compound B
Positron emission tomography
age
tau

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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10.1016/j.jalz.2018.12.016

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Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C. G., Weigand, S. D., Spychalla, A. J., Drubach, D. A., Jack, C. R., Lowe, V. J., & Josephs, K. A. (2019). The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease. Alzheimer's and Dementia, 15(5), 675-685. https://doi.org/10.1016/j.jalz.2018.12.016

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title = "The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease",

abstract = "Introduction: Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD). Methods: Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model. Results: Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance. Discussion: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.",

keywords = "AV-1451, Amyloid, Magnetic resonance imaging, Pittsburgh compound B, Positron emission tomography, age, tau",

author = "Whitwell, {Jennifer L.} and Peter Martin and Jonathan Graff-Radford and Machulda, {Mary M.} and Senjem, {Matthew L.} and Schwarz, {Christopher G.} and Weigand, {Stephen D.} and Spychalla, {Anthony J.} and Drubach, {Daniel A.} and Jack, {Clifford R.} and Lowe, {Val J.} and Josephs, {Keith A.}",

note = "Publisher Copyright: {\textcopyright} 2019 the Alzheimer's Association",

year = "2019",

month = may,

doi = "10.1016/j.jalz.2018.12.016",

language = "English (US)",

volume = "15",

pages = "675--685",

journal = "Alzheimer's and Dementia",

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AU - Whitwell, Jennifer L.

AU - Martin, Peter

AU - Graff-Radford, Jonathan

AU - Machulda, Mary M.

AU - Senjem, Matthew L.

AU - Schwarz, Christopher G.

AU - Weigand, Stephen D.

AU - Spychalla, Anthony J.

AU - Drubach, Daniel A.

AU - Jack, Clifford R.

AU - Lowe, Val J.

AU - Josephs, Keith A.

PY - 2019/5

Y1 - 2019/5

N2 - Introduction: Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD). Methods: Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model. Results: Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance. Discussion: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.

AB - Introduction: Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD). Methods: Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model. Results: Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance. Discussion: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.

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KW - Amyloid

KW - Magnetic resonance imaging

KW - Pittsburgh compound B

KW - Positron emission tomography

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KW - tau

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The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

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