The rise, fall, and possible resurrection of renal denervation

Rajiv Gulati, Claire E. Raphael, Manuela Negoita, Stuart J. Pocock, Bernard J. Gersh

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Renal denervation has a chequered history. Dramatic reductions in blood pressure after denervation of the renal arteries were observed in early trials, but later trials in which denervation was tested against a sham procedure produced neutral results. Although a sound pathophysiological basis exists for interruption of the renal sympathetic nervous system as a treatment for hypertension, trial data to date are insufficient to support renal denervation as an established clinical therapy. In this Perspectives article, we summarize the currently available trial data, device development, and trials in progress, and provide recommendations for future trial design.

Original languageEnglish (US)
Pages (from-to)238-244
Number of pages7
JournalNature Reviews Cardiology
Issue number4
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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