Bilateral defects of 4.5 by 11 mm were made in the distal one-third of the tibias of eight dogs and unilaterally in four dogs. Bone blood flow was measured by 1-Ap washout, tracer deposition of 85Sr was determined, and extraction of 85Sr and [14C]sucrose was measured by the indicator-dilution technique. Endosteal new bone formation was determined by a combined tetracycline-microradiography method. There was a significant correlation between blood flow determined by washout (1-Ap determined over the area of healing bone) and endosteal new bone formation, p < 0.001, expressed as relationships (percent) of the area of new endosteal bone to the total area enclosed by the defect and the medullary cavity of the tibia, p < 0.001. This percentage ranged from 12% to 62% and was directly related to bone blood flow. This suggests that the increase in blood flow in new bone may be secondary to increased metabolic demands.
|Original language||English (US)|
|Number of pages||12|
|Journal||Journal of Laboratory and Clinical Medicine|
|State||Published - 1980|
- I-labeled 4-iodoantipyrine
ASJC Scopus subject areas
- Pathology and Forensic Medicine