@article{674be3bb423145ae9ba26d514f03cc28,
title = "The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson{\textquoteright}s disease",
abstract = "Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson{\textquoteright}s disease at early stages. Methods: A total of 385 Parkinson{\textquoteright}s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson{\textquoteright}s disease may impact disease phenotype.",
keywords = "Constipation, Heterogeneity, Parkinson, Phenotype, Prodromal, Sex",
author = "{on behalf of the PRIAMO study group} and Marina Picillo and Raffaele Palladino and Roberto Erro and Rossella Alfano and Carlo Colosimo and Roberto Marconi and Angelo Antonini and Paolo Barone and Letterio Morgante and D. Benincasa and R. Quatrale and S. Biguzzi and M. Braga and G. Ceravolo and M. Capecci and G. Meco and N. Caravona and R. Scala and {De Falco}, {F. A.} and G. Pezzoli and {De Gaspari}, D. and E. Bottacchi and {Di Giovanni}, M. and A. Cannas and G. Floris and S. Gallerini and L. Grasso and Gaglio, {R. M.} and G. Gurgone and G. Volpe and S. Zappulla and R. Ceravolo and L. Kiferle and S. Ramat and S. Meoni and A. Pisani and V. Moschella and F. Morgante and R. Savica and F. Pepe and G. Ciccarelli and V. Petretta and Giglia, {R. M.} and Randisi, {M. G.} and F. Iemolo and Avarello, {T. P.} and M. Romeno and G. Santangelo and F. Stocchi and G. Sciortino",
note = "Funding Information: Open access funding provided by Universit{\`a} degli Studi di Salerno within the CRUI-CARE Agreement. This study was supported by an educational grant issued by Boehringer-Ingelheim, Italy. Acknowledgements Funding Information: This study was supported by an educational grant issued by Boehringer-Ingelheim, Italy. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2021",
month = feb,
doi = "10.1007/s00415-020-10156-3",
language = "English (US)",
volume = "268",
pages = "448--454",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "2",
}