TY - JOUR
T1 - The prevalence of sleep apnea in type B aortic dissection
T2 - Implications for false lumen thrombosis
AU - Wang, Ling
AU - Chen, Jiyan
AU - Li, Guangxi
AU - Luo, Songyuan
AU - Wang, Rui
AU - Li, Wei
AU - Zhang, Jiawei
AU - Liu, Yuan
AU - Huang, Wenhui
AU - Cao, Yingshu
AU - Zhou, Yingling
AU - Chen, Pingyan
AU - Pressman, Gregg S.
AU - Somers, Virend K.
AU - Luo, Jianfang
N1 - Publisher Copyright:
© 2017, Associated Professional Sleep Societies,LLC. All rights reserved.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Introduction: Obstructive sleep apnea (OSA) has been implicated in aortic dissection. Thrombosis of the false lumen is associated with a prognosis of type B aortic dissection (AoD), and partial thrombosis has been reported to be an independent predictor of mortality. This study sought to explore whether the severity of OSA is associated with false lumen thrombosis. Aims and Methods: In this observational study, 151 type B AoD patients were recruited consecutively from 2013 to 2015. The status of the false lumen was classified as patent, partially thrombosed, or completely thrombosed based on a computer tomography angiography image. Patients were divided into non-OSA group (apnea-hypopnea index [AHI] < 5), and mild (5 ≤ AHI ≤ 15), moderate (15 < AHI ≤ 30), and severe OSA groups (AHI > 30) using the AHI. Results: The prevalence of OSA in type B dissection was 66.2%. Among 151 cases, 51 patients (33.8%) were in the non-OSA group, 56 (37.1%) were in the mild group, 21 (13.9%) were in the moderate group, and 23 (15.2%) were in the severe group. Additionally, a partially thrombosed false lumen was observed in 88 patients (58.3%). Multivariable analysis revealed that OSA severity was positively associated with partial thrombosis (odds ratio, 1.784, 95% confidence interval: 1.182-2.691, P = .006) after adjusting for other confounding factors. Conclusions: OSA was present in two-thirds of patients with type B AoD. The severity of OSA was significantly associated with an increased risk of partial false lumen thrombosis. OSA may therefore be implicated in both the etiology and prognosis of AoD.
AB - Introduction: Obstructive sleep apnea (OSA) has been implicated in aortic dissection. Thrombosis of the false lumen is associated with a prognosis of type B aortic dissection (AoD), and partial thrombosis has been reported to be an independent predictor of mortality. This study sought to explore whether the severity of OSA is associated with false lumen thrombosis. Aims and Methods: In this observational study, 151 type B AoD patients were recruited consecutively from 2013 to 2015. The status of the false lumen was classified as patent, partially thrombosed, or completely thrombosed based on a computer tomography angiography image. Patients were divided into non-OSA group (apnea-hypopnea index [AHI] < 5), and mild (5 ≤ AHI ≤ 15), moderate (15 < AHI ≤ 30), and severe OSA groups (AHI > 30) using the AHI. Results: The prevalence of OSA in type B dissection was 66.2%. Among 151 cases, 51 patients (33.8%) were in the non-OSA group, 56 (37.1%) were in the mild group, 21 (13.9%) were in the moderate group, and 23 (15.2%) were in the severe group. Additionally, a partially thrombosed false lumen was observed in 88 patients (58.3%). Multivariable analysis revealed that OSA severity was positively associated with partial thrombosis (odds ratio, 1.784, 95% confidence interval: 1.182-2.691, P = .006) after adjusting for other confounding factors. Conclusions: OSA was present in two-thirds of patients with type B AoD. The severity of OSA was significantly associated with an increased risk of partial false lumen thrombosis. OSA may therefore be implicated in both the etiology and prognosis of AoD.
KW - False lumen
KW - Sleep apnea
KW - Thrombosis
KW - Type B aortic dissection
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U2 - 10.1093/sleep/zsw071
DO - 10.1093/sleep/zsw071
M3 - Article
C2 - 28364434
AN - SCOPUS:85017190488
SN - 0161-8105
VL - 40
JO - Sleep
JF - Sleep
IS - 3
M1 - zsw071
ER -