TY - JOUR
T1 - The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast
AU - Durand, Nisha
AU - Borges, Sahra
AU - Hall, Tavia
AU - Bastea, Ligia
AU - Döppler, Heike
AU - Edenfield, Brandy H.
AU - Thompson, E. Aubrey
AU - Geiger, Xochiquetzal
AU - Storz, Peter
N1 - Funding Information:
This work was supported by the NIH grant CA184527 to PS. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
Copyright: Durand et al.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific formation of phosphatidylinositol-4,5-bisphosphate (PI4,5P2). By comparing normal breast tissue to carcinoma in situ and invasive ductal carcinoma subtypes, we here show that the phosphorylation status of PIP5K1C at serine residue 448 (S448) can be predictive for breast cancer progression to an aggressive phenotype, while PIP5K1C expression levels are not indicative for this event. PIP5K1C phosphorylation at S448 is downregulated in invasive ductal carcinoma, and similarly, the expression levels of PKD1, the kinase that phosphorylates PIP5K1C at this site, are decreased. Overall, since PKD1 is a negative regulator of cell migration and invasion in breast cancer, the phosphorylation status of this residue may serve as an indicator of aggressiveness of breast tumors.
AB - Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific formation of phosphatidylinositol-4,5-bisphosphate (PI4,5P2). By comparing normal breast tissue to carcinoma in situ and invasive ductal carcinoma subtypes, we here show that the phosphorylation status of PIP5K1C at serine residue 448 (S448) can be predictive for breast cancer progression to an aggressive phenotype, while PIP5K1C expression levels are not indicative for this event. PIP5K1C phosphorylation at S448 is downregulated in invasive ductal carcinoma, and similarly, the expression levels of PKD1, the kinase that phosphorylates PIP5K1C at this site, are decreased. Overall, since PKD1 is a negative regulator of cell migration and invasion in breast cancer, the phosphorylation status of this residue may serve as an indicator of aggressiveness of breast tumors.
KW - Breast cancer
KW - Invasive phenotype
KW - PIP5K1C
KW - Phosphorylation
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U2 - 10.18632/oncotarget.26357
DO - 10.18632/oncotarget.26357
M3 - Article
C2 - 30555634
AN - SCOPUS:85057013008
SN - 1949-2553
VL - 9
SP - 36358
EP - 36370
JO - Oncotarget
JF - Oncotarget
IS - 91
ER -