The pathogenesis of graves' disease

B. McIver, J. C. Morris

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Graves' disease, one of the autoimmune thyroid diseases, is caused by the production of IgG autoantibodies directed against the thyrotropin receptor. These antibodies bind to and activate the receptor, causing the autonomous production of thyroid hormones. Despite recent improvements in out understanding of the cellular and molecular basis of autoimmunity, our currently available treatments for Graves' disease have remained largely unchanged over the last 50 years. Nevertheless, new concepts in immune system regulation hold out the prospect in the future for intervention designed to modify, and possibly cure, the underlying disease process.

Original languageEnglish (US)
Pages (from-to)73-89
Number of pages17
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
StatePublished - 1998

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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