The paracrine effect: Pivotal mechanism in cell-based cardiac repair

Simon Maltais, Jacques P. Tremblay, Louis P. Perrault, Hung Q. Ly

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Cardiac cell therapy has emerged as a controversial yet promising therapeutic strategy. Both experimental data and clinical applications in this field have shown modest but tangible benefits on cardiac structure and function and underscore that transplanted stem-progenitor cells can attenuate the postinfarct microenvironment. The paracrine factors secreted by these cells represent a pivotal mechanism underlying the benefits of cell-mediated cardiac repair. This article reviews key studies behind the paracrine effect related to the cardiac reparative effects of cardiac cell therapy.

Original languageEnglish (US)
Pages (from-to)652-662
Number of pages11
JournalJournal of cardiovascular translational research
Issue number6
StatePublished - Dec 2010


  • Cardiac repair
  • Paracrine effect
  • Stem-Progenitor cells
  • Therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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