TY - JOUR
T1 - The Non-Coding RNA Ontology (NCRO)
T2 - A comprehensive resource for the unification of non-coding RNA biology
AU - Huang, Jingshan
AU - Eilbeck, Karen
AU - Smith, Barry
AU - Blake, Judith A.
AU - Dou, Dejing
AU - Huang, Weili
AU - Natale, Darren A.
AU - Ruttenberg, Alan
AU - Huan, Jun
AU - Zimmermann, Michael T.
AU - Jiang, Guoqian
AU - Lin, Yu
AU - Wu, Bin
AU - Strachan, Harrison J.
AU - He, Yongqun
AU - Zhang, Shaojie
AU - Wang, Xiaowei
AU - Liu, Zixing
AU - Borchert, Glen M.
AU - Tan, Ming
N1 - Funding Information:
Funding for Huang, J was provided in part by the National Cancer Institute (NCI) at the National Institutes of Health (NIH), under the Award Number U01CA180982. Funding for Borchert, GM was provided in part by Natural Science Foundation (NSF) CAREER grant 1350064 (GMB) awarded by Division of Molecular and Cellular Biosciences (with co-funding provided by the NSF EPSCoR program) and in part by the Abraham A. Mitchell Cancer Research Fund. The views contained in this paper are solely the responsibility of the authors and do not represent the official views, either expressed or implied, of the NIH, NSF, the U.S. Government, or the Abraham A. Mitchell Cancer Research Fund.
Publisher Copyright:
© 2016 Huang et al.
PY - 2016/5/4
Y1 - 2016/5/4
N2 - In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users, accessible at: http://purl.obolibrary.org/obo/ncro.owl.
AB - In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users, accessible at: http://purl.obolibrary.org/obo/ncro.owl.
KW - Biomedical ontology
KW - Data annotation
KW - Domain ontology
KW - Non-coding RNA
KW - Ontology development
KW - Reference ontology
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U2 - 10.1186/s13326-016-0066-0
DO - 10.1186/s13326-016-0066-0
M3 - Article
C2 - 27152146
AN - SCOPUS:84965074859
SN - 2041-1480
VL - 7
JO - Journal of Biomedical Semantics
JF - Journal of Biomedical Semantics
IS - 1
M1 - 24
ER -