The neural basis of naming impairments in Alzheimer's disease revealed through positron emission tomography

Maria E. Watson, Kathleen A. Welsh-Bohmer, John M. Hoffman, Val Lowe, David C. Rubin

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The naming impairments in Alzheimer's disease (AD) have been attributed to a variety of cognitive processing deficits, including impairments in semantic memory, visual perception, and lexical access. To further understand the underlying biological basis of the naming failures in AD, the present investigation examined the relationship of various classes of naming errors to regional brain measures of cerebral glucose metabolism as measured with 18 F-Fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). Errors committed on a visual naming test were categorized according to a cognitive processing schema and then examined in relationship to metabolism within specific brain regions. The results revealed an association of semantic errors with glucose metabolism in the frontal and temporal regions. Language access errors, such as circumlocutions, and word blocking nonresponses were associated with decreased metabolism in areas within the left hemisphere. Visuoperceptive errors were related to right inferior parietal metabolic function. The findings suggest that specific brain areas mediate the perceptual, semantic, and lexical processing demands of visual naming and that visual naming problems in dementia are related to dysfunction in specific neural circuits.

Original languageEnglish (US)
Pages (from-to)347-357
Number of pages11
JournalArchives of Clinical Neuropsychology
Issue number4
StatePublished - May 1999

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'The neural basis of naming impairments in Alzheimer's disease revealed through positron emission tomography'. Together they form a unique fingerprint.

Cite this