The natural history of multiple sclerosis: Implications for trial design

Dean M. Wingerchuk, Brian G. Weinshenker

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations


The understanding of the natural history of multiple sclerosis has many implications for the design and interpretation of randomized controlled trials. Selection criteria, patient stratification, outcome measurements, and definitions of treatment failure can influence randomized controlled trial results and limit comparisons among trials. The focus of future studies should shift from short-term determinations of efficacy to definitive evaluations of long-term effectiveness. This will require novel investigative strategies such as the use of historic controls derived from natural history studies.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalCurrent opinion in neurology
Issue number3
StatePublished - 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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