TY - JOUR
T1 - The mouse 5-HT2B receptor
T2 - homologous subtype or species variant?
AU - Choi, Doo Sup
AU - Loric, Sylvain
AU - Colas, Jean François
AU - Callebert, Jacques
AU - Rosay, Philippe
AU - Kellermann, Odile
AU - Launay, Jean Marie
AU - Maroteaux, Luc
PY - 1995/12/15
Y1 - 1995/12/15
N2 - The recently characterized 5-HT2B subfamily of serotonin receptors has now been reported from three different species: human, rat and mouse. Their genomic structures include 2 introns present at identical positions. Despite this similarity, their respective protein sequences show some diversities. In addition, the pharmacology of these receptors is distantly related, and their sites of expression vary amongst species. Thus, it appears difficult at present to unambiguously classify these receptors into the same subfamily, raising the possibility of the existence of other 5-HT2B-like receptors, yet to be discovered.
AB - The recently characterized 5-HT2B subfamily of serotonin receptors has now been reported from three different species: human, rat and mouse. Their genomic structures include 2 introns present at identical positions. Despite this similarity, their respective protein sequences show some diversities. In addition, the pharmacology of these receptors is distantly related, and their sites of expression vary amongst species. Thus, it appears difficult at present to unambiguously classify these receptors into the same subfamily, raising the possibility of the existence of other 5-HT2B-like receptors, yet to be discovered.
KW - Drosophila
KW - Human
KW - Mouse
KW - Rat
KW - Serotonin receptor
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U2 - 10.1016/0166-4328(96)00107-6
DO - 10.1016/0166-4328(96)00107-6
M3 - Article
C2 - 8788513
AN - SCOPUS:0029665349
SN - 0166-4328
VL - 73
SP - 253
EP - 257
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1-2
ER -