The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features

Jeffrey N. Katz, Christine E. Chaisson, Brian Cole, Ali Guermazi, David J. Hunter, Morgan Jones, Bruce A. Levy, Lisa A. Mandl, Scott Martin, Robert G. Marx, Clare Safran-Norton, Frank W. Roemer, Debra Skoniecki, Daniel H. Solomon, Kurt P. Spindler, John Wright, Rick W. Wright, Elena Losina

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled trial (RCT) designed to establish the efficacy of arthroscopic partial meniscectomy combined with a standardized physical therapy program as compared with a standardized physical therapy program alone in patients with a symptomatic meniscal tear in the setting of mild to moderate knee osteoarthritic change (OA). The design and execution of a trial that compares surgery with a nonoperative treatment strategy presents distinctive challenges. The goal of this paper is to provide the clinical rationale for MeTeOR and to highlight salient design features, with particular attention to those that present clinical and methodologic challenges.

Original languageEnglish (US)
Pages (from-to)1189-1196
Number of pages8
JournalContemporary Clinical Trials
Issue number6
StatePublished - Nov 2012


  • Arthroscopic partial meniscectomy
  • Efficacy
  • Meniscal tear
  • Methodology
  • Osteoarthritis
  • Randomized controlled trial

ASJC Scopus subject areas

  • Pharmacology (medical)


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