The metabolism of 1, 25-dihydroxyvitamin Da3

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


VITAMIN D plays a major role in the maintenance of extracellular fluid calcium and phosphorus concentrations, the mineralization of bone, and the maintenance of skeletal integrity (13). The vitamin increases active calcium and phosphorus transport in the duodenum and proximal intestine; rachitic animals and humans have increased feeal losses of calcium that are reversed by the administration of vitamin D. Furthermore, there is evidence that the vitamin or its metabolites have direct effects upon muscle metabolism and on isolated bone cells, and upon the mobilization of calcium from isolated bone (1). Finally, the vitamin has pronounced effects upon the maintenance of adequate growth in experimental animals and in man (1, 3). The present review will focus upon some of the more recent findings concerning the regulation of 25-hydroxyvitamin D3 lα-hydroxylase activity and upon the peripheral metabolism of vitamin D3 homologs.

Original languageEnglish (US)
Pages (from-to)258-267
Number of pages10
JournalEndocrine reviews
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'The metabolism of 1, 25-dihydroxyvitamin Da3'. Together they form a unique fingerprint.

Cite this