@article{7c900d8e6b5d4ee580f1feb53fa18d17,
title = "The Mayo Clinic Experience with the Neurological Complications of the CTLA-4 Inhibitor Ipilimumab",
abstract = "Neurological complications are an increasingly recognized complication of the use of the immune checkpoint inhibitors in the treatment of solid tumors. Ipilimumab is a monoclonal antibody against cytotoxic T-lymphocyte antigen-4, an immune checkpoint inhibitor that suppresses T-cell effector function. The clinical spectrum of ipilimumab-associated neurological complications and optimum treatment approach is not established. We describe our institution's experience with ipilimumab and illustrate 2 cases of presumed autoimmune neurological phenomenon resulting from its use.",
keywords = "CTLA-4, checkpoint inhibitors, general neurology, ipilimumab, neurological complications",
author = "Ruff, {Michael W.} and Mauermann, {Michelle L.}",
note = "Funding Information: From the Department of Neurology, Mayo Clinic, Rochester, MN. M.W.R.: performed the initial draft. M.L.M.: contributed study concept, design, and edited the submission. M.L.M. has received honoraria from the AANEM and AAN for lectures, received honoraria from Continuum Journal for manuscript, consultant fees from IONIS pharmaceuticals for TTR amyloid clinical trial, research support from IONIS pharmaceuticals and Alnylam for TTR amyloid clinical trials, and royalties from Autonomic Disorders book published by Oxford. The remaining author declares no conflict of interest. Reprints: Michael W. Ruff, MD, Mayo Clinic, Department of Neurology, 200 First St SW, Rochester, MN 55905. E-mail: ruff.michael@mayo. edu. Copyright {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 1074-7931/18/2303-0098 DOI: 10.1097/NRL.0000000000000176 Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
doi = "10.1097/NRL.0000000000000176",
language = "English (US)",
volume = "23",
pages = "98--99",
journal = "Neurologist",
issn = "1074-7931",
publisher = "Lippincott Williams and Wilkins",
number = "3",
}