TY - JOUR
T1 - The mayo clinic experience with multimodality treatment of locally advanced or recurrent colon cancer
AU - Taylor, William E.
AU - Donohue, John H.
AU - Gunderson, Leonard L.
AU - Nelson, Heidi
AU - Nagorney, David M.
AU - Devine, Richard M.
AU - Haddock, Michael G.
AU - Larson, Dirk R.
AU - Rubin, Joseph
AU - O'Connell, Michael J.
PY - 2002
Y1 - 2002
N2 - Background: Patients with incompletely resected locally advanced and recurrent colon cancers have a dismal prognosis. Since 1981, 100 colon cancer patients have been treated with combination therapy including surgical resection, chemotherapy, and external plus intraoperative radiotherapy. Methods: A prospective computerized intraoperative radiation database identified patients for this retrospective review. Data collection included patient demographics, tumor and treatment variables, and morbidity, recurrence, and survival statistics. Results: The mean age was 55.2 years. Follow-up was available for all patients. Fifty-nine patients have died. Median follow-up of survivors was 70.5 months. Twenty-five patients with locally advanced colon cancer had a median survival of 38.2 months and a 5-year survival of 49%. Eleven of these patients are still free of disease. Seventy-three patients treated for recurrent colon carcinoma had a median survival of 33.3 months from the time of recurrence, with a 5-year survival of 24.7%. Twenty-one are alive without evidence of recurrence. The 38 patients with recurrent disease whose disease was completely resected had a 37.4% 5-year survival. Conclusions: A multimodality approach using en-bloc surgical resection with radiotherapy and chemotherapy affords some patients with locally advanced and recurrent colon cancer a chance for long-term survival.
AB - Background: Patients with incompletely resected locally advanced and recurrent colon cancers have a dismal prognosis. Since 1981, 100 colon cancer patients have been treated with combination therapy including surgical resection, chemotherapy, and external plus intraoperative radiotherapy. Methods: A prospective computerized intraoperative radiation database identified patients for this retrospective review. Data collection included patient demographics, tumor and treatment variables, and morbidity, recurrence, and survival statistics. Results: The mean age was 55.2 years. Follow-up was available for all patients. Fifty-nine patients have died. Median follow-up of survivors was 70.5 months. Twenty-five patients with locally advanced colon cancer had a median survival of 38.2 months and a 5-year survival of 49%. Eleven of these patients are still free of disease. Seventy-three patients treated for recurrent colon carcinoma had a median survival of 33.3 months from the time of recurrence, with a 5-year survival of 24.7%. Twenty-one are alive without evidence of recurrence. The 38 patients with recurrent disease whose disease was completely resected had a 37.4% 5-year survival. Conclusions: A multimodality approach using en-bloc surgical resection with radiotherapy and chemotherapy affords some patients with locally advanced and recurrent colon cancer a chance for long-term survival.
KW - Intraoperative radiation
KW - Locally advanced
KW - Mulitmodality treatment
KW - Recurrent colon cancer
UR - http://www.scopus.com/inward/record.url?scp=0036210609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036210609&partnerID=8YFLogxK
U2 - 10.1245/aso.2002.9.2.177
DO - 10.1245/aso.2002.9.2.177
M3 - Article
C2 - 11888876
AN - SCOPUS:0036210609
SN - 1068-9265
VL - 9
SP - 177
EP - 185
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 2
ER -