The Learning Curve for Transcatheter Mitral Valve Repair With MitraClip

Mackram F. Eleid, Guy S. Reeder, Joseph F. Malouf, Ryan J. Lennon, Sorin V. Pislaru, Vuyisille T. Nkomo, Charanjit S. Rihal

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objectives: This study sought to assess the learning curve for TMVR for treatment of primary mitral regurgitation (MR). Background: Data are lacking regarding the technical experience required to achieve optimal clinical outcomes with transcatheter mitral valve repair (TMVR) using the edge-to-edge MitraClip technique. Methods: We examined the sequential experience of the first 75 patients (age 80 ± 9 years; 77% male) who underwent TMVR at our institution. A sequence number of each patient was assigned as a continuous variable and in tertiles for analysis. Results: TMVR with MitraClip was successful in 97% with an average procedural time of 106 ± 39 minutes. The 30-day rate of major adverse cardiovascular events was 7%. With increased case experience, there were decreases in procedural time, fluoroscopy time, length of hospital stay, and major adverse cardiovascular events. Procedural success, residual mitral regurgitation and NYHA functional classification at 30-day follow-up remained unchanged throughout the experience. Conclusions: The learning curve for TMVR with MitraClip for treatment of primary MR is characterized by a sequential reduction in procedure time, fluoroscopy time, procedural complications, and hospital length of stay at a tertiary academic medical center. Thirty-day procedural results are favorable and similar during the initial learning period.

Original languageEnglish (US)
Pages (from-to)539-545
Number of pages7
JournalJournal of Interventional Cardiology
Issue number5
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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