The investigation of acute optic neuritis: A review and proposed protocol

Axel Petzold, Mike P. Wattjes, Fiona Costello, Jose Flores-Rivera, Clare L. Fraser, Kazuo Fujihara, Jacqueline Leavitt, Romain Marignier, Friedemann Paul, Sven Schippling, Christian Sindic, Pablo Villoslada, Brian Weinshenker, Gordon T. Plant

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations


Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

Original languageEnglish (US)
Pages (from-to)447-458
Number of pages12
JournalNature Reviews Neurology
Issue number8
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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