The influence of interfering input from the peroneal nerve on tibial-nerve somatosensory evoked potential

Thoru Yamada, Takanori Saito, Yoshihiko Matsue, Yoshiho Honda, Tatsuo Fuchigami, Masami Fujii, Mark Ross

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Using a conditioning-test paradigm, we studied the recovery function of tibial nerve somatosensory evoked potentials (SEPs) conditioned by preceding peroneal nerve stimulation. The inter-stimulus intervals (ISIs) ranged from 0 to 400 msec, where 0 msec indicated simultaneous arrival of tibial and peroneal nerve volleys at the L1 spine. The recovery curve was W-shaped, showing two peaks of SEP suppression, maximum at 6 msec ISI (1st phase) and 50-75 ISI msec (2nd phase). In the 1st phase suppression, we found distinct differences in wave forms between 0-2 msec ISI and 4-6 msec ISI. At 0-2 msec ISI, P40-N50-P60 amplitude decreased and latencies shortened, while P31 and N35 were unchanged. At 4-6 msec ISI, all peaks, possibly excluding P31, were markedly depressed. We attribute the former change to an "occlusive effect" and the latter to an "inhibitory effect," each mediated via a central synaptic network between the two nerves. The attenuation of the 2nd but not the 1st phase suppression by peroneal nerve block distal to the stimulating electrodes provided evidence that the 2nd phase suppression resulted primarily from interfering afferent signals generated by peroneal nerve peripheral receptors, activated by foot movement.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Issue number6
StatePublished - 1992


  • Gating
  • Peroneal nerve
  • Recovery function
  • Somatosensory evoked potential
  • Synaptic inhibition
  • Synaptic occlusion
  • Tibial nerve

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


Dive into the research topics of 'The influence of interfering input from the peroneal nerve on tibial-nerve somatosensory evoked potential'. Together they form a unique fingerprint.

Cite this