TY - JOUR
T1 - The Impact of Microbiota on the Gut–Brain Axis
T2 - Examining the Complex Interplay and Implications
AU - Chaudhry, Tuba Shahid
AU - Senapati, Sidhartha Gautam
AU - Gadam, Srikanth
AU - Mannam, Hari Priya Sri Sai
AU - Voruganti, Hima Varsha
AU - Abbasi, Zainab
AU - Abhinav, Tushar
AU - Challa, Apurva Bhavana
AU - Pallipamu, Namratha
AU - Bheemisetty, Niharika
AU - Arunachalam, Shivaram P.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS. This paper further summarizes the synergetic relation between gastrointestinal and neuropsychological manifestations and emphasizes the need to include behavioral therapies in management plans.
AB - The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS. This paper further summarizes the synergetic relation between gastrointestinal and neuropsychological manifestations and emphasizes the need to include behavioral therapies in management plans.
KW - CNS disorders
KW - GI disorders
KW - central nervous system
KW - cognitive development
KW - enteric nervous system
KW - gastrointestinal diseases
KW - gastrointestinal mobility
KW - gut microbiota
KW - neurological disorders
KW - neurons
KW - second brain
KW - serotonin
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UR - http://www.scopus.com/inward/citedby.url?scp=85169142134&partnerID=8YFLogxK
U2 - 10.3390/jcm12165231
DO - 10.3390/jcm12165231
M3 - Review article
AN - SCOPUS:85169142134
SN - 2077-0383
VL - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 16
M1 - 5231
ER -