The Human Brain Subventricular Zone: Stem Cells in This Niche and Its Organization

Alfredo Quiñones-Hinojosa, Nader Sanai, Oscar Gonzalez-Perez, Jose Manuel Garcia-Verdugo

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Taken together, these observations offer direct evidence that this germinal region is not only organized differently but contains cells with astrocytic characteristics that function as neural stem cells. Considering the size of the human lateral ventricular system, this work suggests that a substantial number of neural stem cells exist in the adult brain throughout life. Understanding the organization of the adult human SVZ represents a necessary first step in understanding the cellular proliferation, precursor migration, and neurogenic niche of the largest known germinal region in the adult human brain-a foundation on which to develop novel neuroregenerative therapies.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalNeurosurgery clinics of North America
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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