The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump

Véronique Sgambato-Faure, Yuning Xiong, Joshua D. Berke, Steven E. Hyman, Emanuel E. Strehler

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The Homer family of scaffold proteins couples NMDA receptors to metabotropic glutamate receptors and links extracellular signals to calcium release from intracellular stores. Ania-3 is a member of the Homer family and is rapidly inducible in brain in response to diverse stimuli. Here, we report the identification of the plasma membrane Ca2+ ATPase (PMCA) as a novel Ania-3/Homer-associated protein. Ania-3/Homer interacts with the b-splice forms of all PMCAs (PMCA1b, 2b, 3b, and 4b) via their PDZ domain-binding COOH-terminal tail. Ectopically expressed Ania-3 colocalized with the PMCA at the plasma membrane of polarized MDCK epithelial cells, and endogenous Ania-3/Homer and PMCA2 are co-expressed in the soma and dendrites of primary rat hippocampal neurons. The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons.

Original languageEnglish (US)
Pages (from-to)630-637
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - May 5 2006


  • Ania-3
  • Calcium signaling
  • Homer
  • Microdomain
  • PDZ domain
  • PMCA
  • Plasma membrane
  • Synaptic function

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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