The History of the Left Atrial Appendage Occlusion

David R. Holmes, Mohamad Alkhouli

Research output: Contribution to journalReview articlepeer-review


Atrial fibrillation (AF) has been a source of fascination for more than 100 years. Most early investigations centered on the mechanisms of the arrhythmia (reentry versus automaticity; site of origin; approaches to treatment or prevention; and the clinical consequences), specifically tachycardia-induced cardiomyopathy and the potential for lethal events in special circumstances (eg, preexcitation syndromes). The current increased interest in AF has been heightened by increasing information on the clinical volume and number of patients affected. Recent data identify a current prevalence rate of 6 million patients in the United States, which is predicted to become 12 million by 2030.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalCardiac Electrophysiology Clinics
Issue number1
StatePublished - Mar 2020


  • Atrial fibrillation
  • Left atrial appendage occlusion
  • Oral anticoagulation
  • Stroke prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'The History of the Left Atrial Appendage Occlusion'. Together they form a unique fingerprint.

Cite this