The hepatocellular secretory pathway

Catherine L. Jackson, Mark A. McNiven

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter focuses on the molecular mechanisms by which nascent proteins and larger cargos are sequestered, packaged into vesicle carriers, and targeted to specific hepatocellular destinations during the secretory process. The secretory pathway begins with synthesis of proteins at the endoplasmic reticulum. The chapter describes some of the molecular components required to direct nascent proteins and more complex lipoprotein particles from the endoplasmic reticulum (ER) to the Golgi apparatus and then to their final destination. Coat protomer I coated vesicles are required for intra-Golgi trafficking and for recycling from the Golgi apparatus back to the ER. The first cis-Golgi element and the trans-Golgi network are tubular membrane meshworks at the entry and exit sides of the Golgi apparatus, respectively. Transport in the anterograde direction from the ER to the Golgi apparatus is mediated by coat protomer II coated vesicles.

Original languageEnglish (US)
Title of host publicationThe Liver
Subtitle of host publicationBiology and Pathobiology
Number of pages11
ISBN (Electronic)9781119436812
ISBN (Print)9781119436829
StatePublished - Jan 24 2020


  • Coat protomer I coated vesicles
  • Coat protomer II coated vesicles
  • Endoplasmic reticulum
  • Golgi apparatus
  • Hepatocellular secretory pathway
  • Intra-Golgi trafficking
  • Trans-Golgi network
  • Very low density lipoprotein

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'The hepatocellular secretory pathway'. Together they form a unique fingerprint.

Cite this