The Heart in Hypertension

Edward D. Frohlich, Carl Apstein, Aram V. Chobanian, Richard B. Devereux, Harriet P. Dustan, Victor Dzau, Fetnat Fauad-Tarazi, Michael J. Horan, Melvin Marcus, Barry Massie, Marc A. Pfeffer, Richard N. re, Edward J. Roccella, Daniel Savage, Clarence Shub

Research output: Contribution to journalReview articlepeer-review

577 Scopus citations


HYPERTENSIVE heart disease can be defined as the response of the heart to the afterload imposed on the left ventricle by the progressively increasing arterial pressure and total peripheral resistance produced by hypertensive vascular disease. Although the response sometimes appears to be out of proportion to the level of the arterial pressure, it is primarily the result of the hemodynamic overload. Hypertension can cause or is related to various cardiac manifestations, among them left ventricular hypertrophy, congestive heart failure, cardiac dysrhythmias, and ischemic heart disease. Although the risk of atherosclerotic coronary heart disease is related to the systolic and diastolic…

Original languageEnglish (US)
Pages (from-to)998-1008
Number of pages11
JournalNew England Journal of Medicine
Issue number14
StatePublished - Oct 1 1992

ASJC Scopus subject areas

  • General Medicine


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