The Global Impact of Hepatic Fibrosis and End-Stage Liver Disease

Young Suk Lim, W. Ray Kim

Research output: Contribution to journalReview articlepeer-review

201 Scopus citations


Hepatic fibrosis is an integral part in the progression of chronic liver disease, ultimately leading to cirrhosis and hepatocellular carcinoma. Globally, alcohol consumption, hepatitis B (HBV) and hepatitis C (HCV) have been the main causes of cirrhosis. More recently, the increasing prevalence of obesity and the metabolic syndrome has resulted in increasing incidence of cirrhosis secondary to nonalcoholic fatty liver disease (NAFLD), especially in developed countries. Chronic liver disease and cirrhosis are important causes of morbidity and mortality in the world. Moreover, the burden of chronic liver disease is projected to increase, due in part to the increasing prevalence of end-stage liver disease and HCC secondary to NAFLD and HCV.

Original languageEnglish (US)
Pages (from-to)733-746
Number of pages14
JournalClinics in liver disease
Issue number4
StatePublished - Nov 2008


  • Cirrhosis
  • End-stage liver disease
  • Epidemiology
  • Global impact
  • Hepatic fibrosis

ASJC Scopus subject areas

  • Hepatology


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