The Glial and Mesenchymal Elements of Gliosarcomas Share Similar Genetic Alterations

Rudolf H. Boerman, Kari Anderl, John Herath, Thomas Borell, Nicola Johnson, Janet Schaeffer-Klein, Allen Kirchhof, Anton K. Raap, Bernd W. Scheithauer, Robert B. Jenkins

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


The cellular origin of the sarcomatous component of gliosarcomas is controversial. It is not clear if the sarcoma arises in transition from the glial cells that comprise the gliomatous component or independently arises from non-neoplastic mesenchymal cells of the tumor stroma. Using comparative genomic hybridization (CGH) along with cytogenetic analysis, fluorescence in situ hybridization (FISH) analysis, and polymerase chain reaction (PCR) analysis of microsatellite allelic imbalance, we have evaluated the genetic alterations in the gliomatous and sarcomatous components of five gliosarcomas. The glial element was grade 4 flbrillary astrocytoma (glioblastoma multiforme) in all five tumors. The sarcoma elements were fibroblastic without osseous, chondroid, or angiosarcomatous differentiation. Gain of chromosome 7, loss of chromosome 10, deletions of the chromosome 9 p-arm, and alterations of chromosome 3 were frequently observed, demonstrating that gliosarcomas can be genetically classified as belonging to the spectrum of glioblastomas. Furthermore, the sarcomatous and gliomatous portions of each gliosarcoma investigated were similar with respect to both the presence and absence of specific genetic alterations. This observation supports the hypothesis that the sarcomatous component of a gliosarcoma either arises from the same common precursor cell as the gliomatous portion, or it arises from the gliomatous portion itself.

Original languageEnglish (US)
Pages (from-to)973-981
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Issue number9
StatePublished - 1996


  • Comparative genomic hybridization (CGH)
  • Genetic alterations
  • Gliosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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