The genetic basis for variation in antibody response to vaccines

Gregory A. Poland, Robert M. Jacobson

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Following a brief review of important concepts of vaccine response and vaccine immunology, recent reports on genetic determinants of vaccine response are reviewed. Recent data demonstrating significant associations with particular human leukocyte antigen genes and responsiveness to measles and hepatitis B vaccines are discussed, along with the influence of Km and Gm allotype genes on pneumococcal polysaccharide vaccines. These recent findings have important considerations for research, vaccine development, and clinical practice.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalCurrent opinion in pediatrics
Issue number2
StatePublished - 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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