The ensemble male hypothalamo-pituitary-gonadal axis

Johannes D. Veldhuis; Daniel M. Keenan; Ali Iranmanesh; Paul Y. Takahashi; Ajay Nehra

The ensemble male hypothalamo-pituitary-gonadal axis

Johannes D. Veldhuis, Daniel M. Keenan, Ali Iranmanesh, Paul Y. Takahashi, Ajay Nehra

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain, fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone concentrations fall by 0.8% to 1.5% per year and are reduced by 30% by the seventh compared with third decade of life. Sexhormone binding globulin (SHBG) concentrations rise twofold in older males. Estradiol bioavailability declines along with that of testosterone, probably contributing to reduced bone density, elevated follicle-stimulating hormone (FSH) concentrations, and decreased prolactin concentrations. Although testis size and firmness diminish, spermatogenesis may be relatively preserved in elderly men.

Original language	English (US)
Title of host publication	Physiological Basis of Aging and Geriatrics, Fourth Edition
Publisher	CRC Press
Pages	185-203
Number of pages	19
ISBN (Electronic)	9781420007091
ISBN (Print)	9780849373053
State	Published - Jan 1 2007

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

Cite this

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title = "The ensemble male hypothalamo-pituitary-gonadal axis",

abstract = "Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain, fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone concentrations fall by 0.8% to 1.5% per year and are reduced by 30% by the seventh compared with third decade of life. Sexhormone binding globulin (SHBG) concentrations rise twofold in older males. Estradiol bioavailability declines along with that of testosterone, probably contributing to reduced bone density, elevated follicle-stimulating hormone (FSH) concentrations, and decreased prolactin concentrations. Although testis size and firmness diminish, spermatogenesis may be relatively preserved in elderly men.",

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AU - Veldhuis, Johannes D.

AU - Keenan, Daniel M.

AU - Iranmanesh, Ali

AU - Takahashi, Paul Y.

AU - Nehra, Ajay

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain, fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone concentrations fall by 0.8% to 1.5% per year and are reduced by 30% by the seventh compared with third decade of life. Sexhormone binding globulin (SHBG) concentrations rise twofold in older males. Estradiol bioavailability declines along with that of testosterone, probably contributing to reduced bone density, elevated follicle-stimulating hormone (FSH) concentrations, and decreased prolactin concentrations. Although testis size and firmness diminish, spermatogenesis may be relatively preserved in elderly men.

AB - Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain, fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone concentrations fall by 0.8% to 1.5% per year and are reduced by 30% by the seventh compared with third decade of life. Sexhormone binding globulin (SHBG) concentrations rise twofold in older males. Estradiol bioavailability declines along with that of testosterone, probably contributing to reduced bone density, elevated follicle-stimulating hormone (FSH) concentrations, and decreased prolactin concentrations. Although testis size and firmness diminish, spermatogenesis may be relatively preserved in elderly men.

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BT - Physiological Basis of Aging and Geriatrics, Fourth Edition

PB - CRC Press

ER -

The ensemble male hypothalamo-pituitary-gonadal axis

Abstract

ASJC Scopus subject areas

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