The effect of hyperbaric oxygenation and hypoxia on the blood-nerve barrier

James D. Schmelzer; Phillip A. Low

doi:10.1016/0006-8993(88)90861-X

The effect of hyperbaric oxygenation and hypoxia on the blood-nerve barrier

James D. Schmelzer, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We measured the permeability coefficient-surface area product (PA) of peripheral nerve to [¹⁴C]sucrose in rat sciatic nerve in experimental chronic hypoxic hypoxia of up to 8 weeks and following hyperbaric oxygenation for 1 to 4 weeks. Chronic hypoxia caused an increase in PA presumably indicating impairment of the blood-nerve barrier at 4 weeks with restoration to normal by 8 weeks. Hyperbaric oxygenation (100% oxygen at 2.5 ata for 120 min/day 5 days per week) caused a mild but time dependent increase in PA reaching statistical significance by 4 weeks.

Original language	English (US)
Pages (from-to)	321-326
Number of pages	6
Journal	Brain Research
Volume	473
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90861-X
State	Published - Nov 15 1988

Keywords

Blood-nerve barrier
Hyperbaric oxygenation
Hypoxia
Peripheral nerve
Rat

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)90861-X

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title = "The effect of hyperbaric oxygenation and hypoxia on the blood-nerve barrier",

abstract = "We measured the permeability coefficient-surface area product (PA) of peripheral nerve to [14C]sucrose in rat sciatic nerve in experimental chronic hypoxic hypoxia of up to 8 weeks and following hyperbaric oxygenation for 1 to 4 weeks. Chronic hypoxia caused an increase in PA presumably indicating impairment of the blood-nerve barrier at 4 weeks with restoration to normal by 8 weeks. Hyperbaric oxygenation (100% oxygen at 2.5 ata for 120 min/day 5 days per week) caused a mild but time dependent increase in PA reaching statistical significance by 4 weeks.",

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AU - Low, Phillip A.

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N2 - We measured the permeability coefficient-surface area product (PA) of peripheral nerve to [14C]sucrose in rat sciatic nerve in experimental chronic hypoxic hypoxia of up to 8 weeks and following hyperbaric oxygenation for 1 to 4 weeks. Chronic hypoxia caused an increase in PA presumably indicating impairment of the blood-nerve barrier at 4 weeks with restoration to normal by 8 weeks. Hyperbaric oxygenation (100% oxygen at 2.5 ata for 120 min/day 5 days per week) caused a mild but time dependent increase in PA reaching statistical significance by 4 weeks.

AB - We measured the permeability coefficient-surface area product (PA) of peripheral nerve to [14C]sucrose in rat sciatic nerve in experimental chronic hypoxic hypoxia of up to 8 weeks and following hyperbaric oxygenation for 1 to 4 weeks. Chronic hypoxia caused an increase in PA presumably indicating impairment of the blood-nerve barrier at 4 weeks with restoration to normal by 8 weeks. Hyperbaric oxygenation (100% oxygen at 2.5 ata for 120 min/day 5 days per week) caused a mild but time dependent increase in PA reaching statistical significance by 4 weeks.

KW - Blood-nerve barrier

KW - Hyperbaric oxygenation

KW - Hypoxia

KW - Peripheral nerve

KW - Rat

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The effect of hyperbaric oxygenation and hypoxia on the blood-nerve barrier

Abstract

Keywords

ASJC Scopus subject areas

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