The effect of hyperbaric oxygenation and hypoxia on the blood-nerve barrier

James D. Schmelzer, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We measured the permeability coefficient-surface area product (PA) of peripheral nerve to [14C]sucrose in rat sciatic nerve in experimental chronic hypoxic hypoxia of up to 8 weeks and following hyperbaric oxygenation for 1 to 4 weeks. Chronic hypoxia caused an increase in PA presumably indicating impairment of the blood-nerve barrier at 4 weeks with restoration to normal by 8 weeks. Hyperbaric oxygenation (100% oxygen at 2.5 ata for 120 min/day 5 days per week) caused a mild but time dependent increase in PA reaching statistical significance by 4 weeks.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalBrain Research
Issue number2
StatePublished - Nov 15 1988


  • Blood-nerve barrier
  • Hyperbaric oxygenation
  • Hypoxia
  • Peripheral nerve
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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