The effect of age on protein metabolism

Kevin R. Short, K. Sreekumaran Nair

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


The mechanisms of senescence remain to be fully defined. This review focuses on recent advances in our understanding of body protein turnover, which is essential for the remodeling of tissues and production of specific proteins in time of need. Recent advances in technology make it possible to measure the synthesis rate of muscle myosin heavy chain, mitochondrial proteins and sarcoplasmic proteins, providing insight into the mechanisms of the sarcopenia of aging. A reduced synthesis rate of myosin heavy chain and mitochondrial protein may explain muscle weakness and fatiguability that occurs with aging. Aging also seems to affect selected liver proteins such as fibrinogen. The potential roles of exercise and hormone replacement in slowing the age-related decline in protein turnover is discussed. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalCurrent opinion in clinical nutrition and metabolic care
Issue number1
StatePublished - Jan 2000

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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